COMPLEX BIOLOGICAL SYSTEMS

Complex fuzzy linear systems

Cooperativity in biological systems

Living organisms can sense and respond to external and internal stimuli. Response isdemonstrated in many forms including modulation of gene expression profiles, motility,secretion, cell death, etc. Nevertheless, all forms share a basic property: they depend on sensingsmall changes in the concentration of an effector molecule or subtle conformational changes ina protein and invoking the appropri...

Probing complex biological systems with simple chemistry.

A simplified chemical model helps elucidate the spatiotemporal dynamics of blood clotting.

Mathematical Modeling of Complex Biological Systems

To understand complex biological systems such as cells, tissues, or even the human body, it is not sufficient to identify and characterize the individual molecules in the system. It also is necessary to obtain a thorough understanding of the interaction between molecules and pathways. This is even truer for understanding complex diseases such as cancer, Alzheimer's disease, or alcoholism. With ...

Why complex systems engineering needs biological development

Here we shall discuss the need of Complex Systems Engineering to adopt principles from natural development of complex biological organisms—besides principles of natural evolution—to acomplish the type of performance that biology achieves regularly. We shall situate Complex Systems Engineering and discuss an example of how it could be employed. © 2007 Wiley Periodicals, Inc. Complexity 13:12–21,...